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Suppressing implant fibrosis
Volume 18 Issue 8, August 2019
Foreign body response can result in failure of biomaterials in vivo. Solvent-free crystals containing anti-fibrotic drugs now show the potential for long-term inhibition of fibrosis on a number of implantable devices in rodents and non-human primates.
See Farah et al. and Bank News & Views.
foreign body reaction to Biomaterials
Volume 16 Issue 6, June 2017
By studying the immune responses of animals to different types of biomaterial implants, colony stimulating factor-1 receptor is revealed as an important mediator of the foreign body reaction and a possible target for fibrosis inhibition.
Volume 31, Issue 44, 26 October 2021
Many medical implants provoke a foreign body response (FBR) postimplantation, causing treatment failure. In article number 2010929, Shady Farah and co-workers describe the recent technologies to mitigate FBR, in order to enhance the success of implantable medical devices, biocompatibility, and long-term functionality. This comprehensive review discusses the concept with respect to drug delivery systems and surface modifications and their recent advances with appropriate examples.
WATER PURIFICATION BEADS
Volume 54, Issue 5, 1 March 2016
On page 596 (DOI: 10.1002/pola.27894), Shady Farah, Avi Domb, and co-workers discuss the synthesis of N-bromo-5,5'-dimethylhydantoin conjugated polystyrene beads, and examine parameters such as particle size, crosslinking, and nano-micro porosity to determine their effect on oxidative halogen release. Notably, the rate of halogen release influences antimicrobial activity, which determines the material's use in water purification applications. The bead's nano-micro characteristics were found to be critical in controlling oxidative halogen release. The synthesized beads exhibited strong and extended antimicrobial activity for hundreds of liters of passing contaminated water.
Antimicrobial Materials for Biomedical Applications
02 Aug 2019
About this book
With the need to combat emerging infectious diseases, research around antimicrobial biomaterials and their applications is booming. This book provides the field with a much-needed fundamental overview of the science, addressing the chemistry of a broad range of biomaterial types, and their applications in the biomedical industry.
Materials covered include polymers, from those with inherent antimicrobial activity to those that release antimicrobial agents, antimicrobial ceramics and inorganic compounds, such as metal based antimicrobial additives, and the developing field of biomimetic materials, are discussed. Surfaces, coatings and adhesives are covered, whilst the applications of these antimicrobial materials in biomedical applications, from catheters to orthopaedics, dentistry to ophthalmology, are explored.
Edited by international leaders and with contributions from the best in the field, this book is the go-to resource for graduates and researchers in biomaterials science, biomedical engineering, chemical engineering, and materials and polymer chemistry.